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Literature summary extracted from

  • Pojer, F.; Ferrer, J.L.; Richard, S.B.; Nagegowda, D.A.; Chye, M.L.; Bach, T.J.; Noel, J.P.
    Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases (2006), Proc. Natl. Acad. Sci. USA, 103, 11491-11496.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.3.10 synthesis use of crystal structure of enzyme in complex with inhibitor (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid as starting point for structure-based design of inhibitors Brassica juncea

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.3.10 bound covalently via Cys 117 to inhibitor (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid, and in complex with acetyl-CoA and hydroxymethylglutaryl-CoA Brassica juncea

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.10 (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid i.e. F-244 Brassica juncea

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Brassica juncea
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