Literature summary extracted from
Pojer, F.; Ferrer, J.L.; Richard, S.B.; Nagegowda, D.A.; Chye, M.L.; Bach, T.J.; Noel, J.P.
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases (2006), Proc. Natl. Acad. Sci. USA, 103, 11491-11496.
Application
EC Number |
Application |
Comment |
Organism |
---|
2.3.3.10 |
synthesis |
use of crystal structure of enzyme in complex with inhibitor (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid as starting point for structure-based design of inhibitors |
Brassica juncea |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
2.3.3.10 |
bound covalently via Cys 117 to inhibitor (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid, and in complex with acetyl-CoA and hydroxymethylglutaryl-CoA |
Brassica juncea |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
2.3.3.10 |
(E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid |
i.e. F-244 |
Brassica juncea |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.3.3.10 |
Brassica juncea |
- |
- |
- |